CarMax, Gilead and Sarepta rise premarket; Nvidia falls

Investing.com -- U.S. stock futures edged lower Friday, ending a winning week on a negative note ahead of the release of key economic activity data.

Here are some of the biggest premarket U.S. stock movers today:

• Nvidia (NASDAQ:NVDA) stock fell 1.7% after tech investor Paul Wick of Seligman Investments reduced his stake in the chip maker. The stock has nearly tripled this year, briefly resulting in the company claiming the largest market capitalization in the world.

• Microsoft (NASDAQ:MSFT) stock fell 0.1%, slipping slightly despite regaining the title as the world’s most valuable company.

• Boeing (NYSE:BA) stock fell 0.2% after Reuters reported that the aircraft manufacturer is on the verge of agreeing to repurchase Spirit Aerosystems (NYSE:SPR), up 4.1%, its former subsidiary.

• Amazon (NASDAQ:AMZN) stock rose 0.2% after Reuters reported that the online retail giant is planning a major revamp of its decade-old money-losing Alexa service to include a conversational generative AI with two tiers of service.

• Sarepta Therapeutics (NASDAQ:SRPT) stock rose 37% after U.S. regulators approved the biotech’s request to widen access for its gene therapy that treats a rare muscle wasting disease.

• Gilead Sciences (NASDAQ:GILD) stock rose 3.1% after the biotech said its experimental twice-yearly medicine to prevent HIV was 100% effective in a late-stage trial.

• CarMax (NYSE:KMX) stock rose 1% after the used vehicle retailer’s first-quarter profit came in stronger-than-expected, even after dropping 33%, while its sales missed estimates.